Our group is fortunate to collaborate with many incredible scientists. Some recent past and present collaborators include:
Understanding particle movement data in cells
Rapid advancements in imaging have led to an abundance of trajectory data of stuff moving around inside cells. However, what to do with this data isn't totally clear.
Our work in this realm has been adapting statistics & data science tools to connect mechanistic models of movement with particle data, especially in mitosis and intracellular transport.
Stochastic models of the cytoskeleton & motors
Cells rely on teams of motor proteins to perform vital tasks including carrying cargo enormous distances and coordinating mitosis. These motors behave randomly as individuals yet unite harmoniously.
A central theme of my research pursues the question: how does the randomness of individual motors affect their ability to function collectively?
Information flow in ligand/receptor signaling
Cells transmit signals by releasing particles (ligands) that diffuse around in search of targets (receptors), an inherently random process that can be studied mathematically using PDEs and singular perturbationtheory.
We are interested in understanding how spatial organization (e.g. movement, clustering) affects the cell's ability to extract information from this noisy communication procedure.