Komarova, N.L. and Wodarz, D. (2013) Dynamics of cancer: mathematical foundations of oncology. World Scientific Publishing.
Wodarz, D. and Komarova. N.L. (2005) Computational Biology of Cancer: Lecture notes and mathematical modeling. World Scientific Publishing.
Uhl, P., Lowengrub, J., Komarova, N., & Wodarz, D. (2021). Spatial dynamics of feedback and feedforward regulation in cell lineages.
Patel, A. G., Chen, X., Huang, X., Clay, M. R., Komarova, N., Krasin, M. J., ... & Dyer, M. A. (2021). The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma.
Weiss, L. D., van den Driessche, P., Lowengrub, J. S., Wodarz, D., & Komarova, N. L. (2021). Effect of feedback regulation on stem cell fractions in tissues and tumors: Understanding chemoresistance in cancer. Journal of Theoretical Biology, 509, 110499.
Bailey, L. D., & Komarova, N. L. (2021). Cellular feedback networks and their resilience against mutations. Journal of Biological Systems, 29(02), 325-374.
Paul, D., & Komarova, N. L. (2021). Multi-scale network targeting: A holistic systems-biology approach to cancer treatment. Progress in Biophysics and Molecular Biology.
Komarova, N. L. & Wodarz, D. (2021). Mathematical and Systems Medicine Approaches to Resistance Evolution and Prevention in Cancer. In: Wolkenhauer, Olaf (ed.). Systems Medicine: Integrative, Qualitative and Computational Approaches, vol. 3, pp. 247-260. Oxford: Elsevier.
Komarova, N. L. (2020). Mathematics of Cellular Evolution and Some Biomedical Applications. Notices of the American Mathematical Society, 67(5).
Wodarz, D., & Komarova, N. L. (2020). Mutant Evolution in Spatially Structured and Fragmented Expanding Populations. Genetics 216 (1), 191--203.
Komarova, N. L., Boland, C. R., Goel, A., & Wodarz, D. (2020). Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, e1487.
Shimura, Tadanobu, Shusuke Toden, Natalia L. Komarova, Richard C. Boland, Dominik Wodarz, and Ajay Goel. (2020) A comprehensive in vivo and mathematical modeling-based kinetic characterization for aspirin-induced chemoprevention in colorectal cancer. Carcinogenesis 41(6), 751-760.
Rockne, Russell C., Andrea Hawkins-Daarud, Kristin R. Swanson, James P. Sluka, James A. Glazier, Paul Macklin, David A. Hormuth II et al. (2019) The 2019 mathematical oncology roadmap. Physical biology 16, no. 4: 041005.
Rodriguez-Brenes, I.A., Komarova, N.L., Wodarz, D. (2019) The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach. Journal of Theoretical Biology 460, 144--152.
Farhang-Sardroodi, S., Darooneh, A.H., Kohandel, M. and Komarova, N.L. (2019) Environmental spatial and temporal randomness and its role in non-favored mutant dynamics. Journal of the Royal Society Interface 16(157), 20180781.
Alvarado, C., Wearing, H.J., Komarova, N.L. (2018) Optimizing homeostatic cell renewal in hierarchical tissues. PLOS Comp. Bio. 14(2), e1005967.
Wodarz, D., Newell, A.C., Komarova, N.L. (2018) Passenger mutations can accelerate tumor suppressor gene inactivation in cancer evolution. Journal of The Royal Society Interface, 15(143), 20170967.
Alvarado, C., Fider, N., Wearing, H.J., Komarova, N.L. (2018) Optimizing homeostatic cell renewal in hierarchical tissues. PLOS Comp. Bio. 14(2), e1005967.
Farhang-Sardroodie, S., Darooneh, A.H., Nikbakht, M., Komarova, N.L., Kohandel, M. (2017) The effect of randomness on the average fixation time of mutants. PLoS Comp. Bio. 13(11), e1005864.
Wodarz, D., Goel, A., Komarova, N.L. (2017) Effect of cell cycle duration on somatic evolutionary dynamics. Evolutionary Applications, DOI: 10.1111/eva.12518.
Wodarz, D., Goel, A., Boland, C.R., Komarova, N.L. (2017) Effect of aspirin on tumor cell colony formation and evolution. Journal of The Royal Society Interface, 14(134), 20170374.
Mahdipour-Shirayeh, A., Darooneh, A. H., Long, A. D., Komarova, N.L., Kohandel, M. (2017) Genotype by random environmental interactions gives an advantage to non-favored minor alleles. Scientific Reports 7: 5193.
Yang, J., Axelrod, D., Komarova, N.L. (2017) Determining the control networks regulating stem cell lineages in colonic crypts. Journal of Theoretical Biology 429: 190--203.
Zhang, J., Fleischman, A., Wodarz, D. & Komarova, N.L. (2017) Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms. Journal of Theoretical Biology 425: 43--52.
Komarova, N.L. & van den Driessche, P. (2017) Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages. Bulletin of Mathematical Biology (2017): 1-21.
Zumwalt, T., Wodarz, D., Komarova, N.L., Shusuke, T., Turner, J., Cardenas, J., Burn, J., Chan, A., Boland, C.R., Goel, A. (2017) Aspirin-induced chemoprevention and response kinetics are enhanced by PIK3CA mutations in colorectal cancer cells. Cancer Prevention Research. DOI: 10.1158/1940-6207.CAPR-16-0175
Shahriyari, L., Komarova, N.L., Jilkine, A. (2016) The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts, Biology Direct 11(1), 42.
Sun, Z., Plikus MV, Komarova NL (2016). Near equilibrium calculus of stem cells in application to the airway epithelium lineage. PloS Computational Biology. 12(7), e1004990.
Rodriguez-Brenes, I. A., Wodarz, D., & Komarova, N. L. (2016). Cellular replication limits in the Luria-Delbrück mutation model. Physica D: Nonlinear Phenomena, 328, 44-51.
Asatryan, A. D., & Komarova, N. L. (2016). Evolution of genetic instability in heterogeneous tumors. Journal of theoretical biology, 396, 1-12.
Komarova, N. L. (2015). The benefits of treating undetectable tumors. eLife, 4, e09713.
Yang, J., Plikus, M. V., & Komarova, N. L. (2015). The Role of Symmetric Stem Cell Divisions in Tissue Homeostasis. PLoS Comput Biol, 11(12), e1004629.
Rodriguez-Brenes, I. A., Wodarz, D., & Komarova, N. L. (2015). Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy. Scientific reports, 5.
Komarova, N.L. (2015) Cancer: a moving target. Nature, 525(7568), 198-199. (News and Views article).
Shahriyari, L. and Komarova, N.L. (2015) The role of the bi-compartmental stem cell niche in delaying cancer. Phys. Bio. 12(5): 055001.
Yang, J., Sun, Z., and Komarova, N.L. (2015) Analysis of stochastic stem cell models with control. Mathematical Biosciences 266: 93--107.
Rodrigues-Brenes, I. A., Wodarz, D. and Komarova, N.L. (2015) Characterizing inhibited tumor growth in stem-cell-driven non-spatial cancers. Mathematical Biosciences doi:10.1016/j.mbs.2015.08.009
Toden, S., Okugawa, Y., Jascur, T., Wodarz, D., Komarova, N. L., Buhrmann, C., ...& Goel, A. (2015) Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis, 36(3), 355-367.
Kaveh, K, Komarova, N.L., and Kohandel, M. (2015) The duality of spatial death-birth and birth-death processes and limitations of the isothermal theorem. Royal Society Open Science 2: 140465.
Komarova, N.L., Burger, J.A., Wodarz, D. (2014) Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL). Proceedings of the National Academy of Sciences.
Komarova, N. L. (2014). Spatial interactions and cooperation can change the speed of evolution of complex phenotypes. Proceedings of the National Academy of Sciences, 201400828.
Jackson, T.L., Komarova, N.L. and Swanson, K.R. (2014) Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries. American Mathematical Monthly.
Wodarz, D., Garg, N., Komarova, N. L., Benjamini, O., Keating, M. J., Wierda, W. G., Kantarjian, H., James, D., O'Brien, S. & Burger, J. A. (2014). Kinetics of chronic lymphocytic leukemia (CLL) cells in tissues and blood during therapy with the BTK inhibitor ibrutinib. Blood, blood-2014.
Manem, V.S.K., M. Kohandel, M., Komarova, N.L., Sivaloganathan, S. (2014) Spatial invasion dynamics on random and unstructured meshes: Implications for heterogeneous tumor populations. Journal of Theor. Biol. 349, 66--73.
Komarova, N.L., Shahriyari, L. and Wodarz, D. (2014) Complex role of space in the crossing of fitness valleys by asexual populations. Jour of the Roy Soc Interface, 11(95), 20140014.
Rodrigues-Brenes, I. A., Komarova, N.L., Wodarz, D. (2014) Cancer-associated mutations in healthy individuals: assessing the risk of carcinogenesis. Cancer Research, 74(6), 1661-1669.
Shahriyari, L. and Komarova, N.L. (2013) Symmetric vs asymmetric stem cell divisions: an adaptation against cancer? PLoS One, 8: e76195.
Komarova, N.L. and Boland, C.R. (2013) Cancer: Calculated treatment. Nature 499, 291-292 ( News and Views article).
Komarova, N.L. (2013) Principles of regulation of self-renewing cell lineages. PLoS One 8(9), e72847.
Rodrigues-Brenes, I. A., Wodarz, D., Komarova, N.L. (2013) Minimizing the risk of cancer: tissue architecture and cellular replication limits. Jour Roy Soc Interface 10(86), 1--12.
Rodrigues-Brenes, I. A., Wodarz, D., Komarova, N.L. (2012) Stem cell control, oscillations and tissue regeneration in spatial and non-spatial models. Front. Oncol. 3:82.
Wodarz, D., Boland, C.R., Goel, A., Komarova, N.L. (2013) Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines. Biology Direct. 8(1), 1--14.
Komarova, N.L. (2013) Spatial stochastic models of cancer: fitness, migration, invasion. Mathematical Biosciences and Engineering 10, pp. 761--775.
Sun, Z., Komarova, N.L. (2013) Stochastic control of proliferation and differentiation in stem cell dynamics. To appear in Jour. Math. Bio.
Wodarz, D., Hofacre, A., Lau, J.W., Sun, Z., Fan, H., Komarova, N.L. (2012) Complex spatial dynamics of oncolytic viruses in vitro: mathematical and experimental approaches. PLoS Computational Biology, 8(6): e1002547.
Komarova, N.L., Urwin, E., Wodarz, D. (2012) Accelerated crossing of fitness valleys through division of labor and cheating. Scientific Reports. 2:917.
Sorace, R., Komarova, N.L. (2012) Accumulation of neutral mutations in growing cell colonies with competition. Jour. of Theor. Biol. 314, 84-94.
Sun, Z., Komarova, N.L. (2012) Stochastic control of proliferation and differentiation in stem cell dynamics. To appear in Jour. Math. Bio.
Komarova, N.L., Urwin, E., Wodarz, D. (2012) Accelerated crossing of fitness valleys through division of labor and cheating. To appear in Scientific Reports.
Sorace, R., Komarova, N.L. (2012) Accumulation of neutral mutations in growing cell colonies with competition. To appear in Jour. of Theor. Biol.
Sun, Z., Komarova, N.L. (2012) Stochastic modeling of stem-cell dynamics with control. To appear in Math. Biosciences.
Rodrigues-Brenes, I. A., Komarova, N.L., Wodarz, D. (2011) Evolutionary dynamics of feedback escape and the development of stem-cell driven cancers. PNAS 108(47) 18983-18988.
Komarova, N.L. (2011) ``Cancer initiation and progression, modeling''. Encyclopedia of Applied and Computational Mathematics. Springer.
Komarova. N.L.(2011) Mathematical modeling of cyclic treatments of chronic myeloid leukemia Math Biosci and Engineering 8(2): 289--306.
Komarova, N.L. (2010) Modeling approaches to studying stem cells in cancer. In S.Sivaloganathan (ed.) New perspectives in mathematical biology (Fields Institute Communications), American Mathematical Society, Providence, Rhode Island.
Katouli, A.A., Komarova. N.L. (2010) Optimizing combination therapies with existing and future CML drugs. PLoS One 5(8):e12300.
Wan, F.M.Y., Sadovsky, A.V. and Komarova, N.L. (2010) Genetic Instability in Cancer: An Optimal Control Problem. Studies in Applied Mathematics 125 (1): 1 --38.
Thalhauser CJ, Lowengrub JS, Stupack D, Komarova NL. (2010) Selection in spatial stochastic models of cancer: migration as a key modulator of fitness. Biol Direct.
Katouli AA, Komarova NL. (2010) The Worst Drug Rule Revisited: Mathematical Modeling of Cyclic Cancer Treatments. Bull Math Biol.
Komarova NL, Wodarz D.(2010) ODE models for oncolytic virus dynamics. J Theor Biol. 263(4):530-43.
Komarova, N.L. & Wodarz, D. (2009) Combination therapies against chronic myeloid leukemia: short term versus long term strategies. Cancer Res. 69, 4904.
Komarova, N.L., Katouli, A.A. & Wodarz, D. (2009) Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia. PLoS One 4(2):e4423.
Komarova, N.L. & Wodarz, D. (2009) Towards predictive computational models of oncolytic virus dynamics in vitro. PLoS One (1):e4271.
Boland, C.R., Komarova, N.L. & Goel, A. (2009) Chromosomal instability and cancer: not just one CINgle mechanism. Gut 58(2):163-4.
Komarova, N.L., Sadovsky, A.V. and Wan, F.M.Y. (2008) Selective pressures for and against genetic instability in cancer: a time-dependent problem. Jour. of the Royal Society Interface, 5(18): 105-21.
Komarova, N.L. and Wodarz, D. (2007) Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancer. Theor Popul Bio. 72(4):523-38.
Komarova, N.L. and Wodarz, D. (2007) Effect of cellular quiescence on the success of targeted CML therapy. PloS ONE, 2(10):e990.
Komarova, N.L. and Wodarz, D. (2007) Cancer as a microevolutionary process. To appear in Evolution in health and disease, 2nd edition, Oxford University Press (Ed: Stephen Stearns and Jacob Koella).
Komarova, N.L., Wodarz, D., Boland, C.R. & Goel, A. (2007) Genetic and epigenetic pathways to colon cancer: relating experimental evidence with modeling. To appear in Nicola Bellomo, Mark Chaplain, and Elena De Angelis (Eds), Selected topics on cancer modeling: genesis - evolution - immune competition - therapy. Birkhauser, Boston.
Komarova, N.L. (2007) Stochastic Modelling of Loss- and Gain-of-Function Mutations in Cancer. Mathematical Models and Methods in Applied Sciences 17S: 1647-1773.
Komarova, N.L. (2007) Stochastic modeling of loss- and gain-of-function mutations in cancer. To appear in Nicola Bellomo, Mark Chaplain, and Elena De Angelis (Eds), Selected topics on cancer modeling: genesis - evolution - immune competition - therapy. Birkhauser, Boston.
Komarova, N.L., Baldi, P. and Wu, L. (2007) The fixed-size Luria-Delbruck model with a nonzero death rate. Math. Biosciences 210(1):253-90.
Komarova, N.L. (2007) Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models. Jour. Stat. Phys. 128, pp. 413-446.
Wodarz, D. and Komarova, N.L. (2007) Can loss of apoptosis protect against cancer? Trends in Genetics 23(5), pp. 232-7.
Komarova, N.L. (2006) Spatial stochastic models of cancer initiation and progression. Bull. Math. Biol. 68(7), pp. 1573-99.
Komarova, N.L. (2006) Stochastic modeling of drug resistance in cancer. Jour. Theor. Biol. , 239(3), pp. 351-366.
Komarova, N.L. & Cheng, P. (2006) Epithelial tissue architecture protects against cancer. Math Biosciences , 200(1), pp 90-117.
Wodarz, D. and Komarova, N.L. (2005) Evolutionary dynamics of drug resistance in cancer (review). Gene Therapy and Mol. Biol. 9, pp. 247-256.
Komarova, N.L. (2005) Cancer, aging and the optimal tissue design. Semin Cancer Biol., 15(6), pp. 494-505.
Wodarz, D. & Komarova, N.L. (2005) Emergence and prevention of resistance against small molecule inhibitors. Semin Cancer Biol. 15(6), pp. 506-14.
Komarova, N.L. & Wodarz, D. (2005) Drug resistance in cancer: principles of emergence and prevention. Proc. Natl. Acad. Sci. 102 (27), pp. 9714-9.
Komarova, N.L. & Mironov, V. (2005) On the role of endothelial progenitor cells in tumor neovascularization. Jour. Theor. Biol. 235 (3), pp. 338-49
Komarova, N.L. (2005) Mathematical modeling of tumorigenesis: mission possible. Curr. Oncology 17(1), pp. 39-43.
Iwasa, Y., Michor, F., Komarova, N.L. and Nowak, M. (2005) Population genetics of tumor suppressor genes. Jour. Theor. Biol. 233 pp. 15-23.
Wodarz, D., Iwasa, Y., and Komarova, N.L. (2004) On the emergence of multifocal cancers. Jour. of Carcinogenesis 3(1) 13.
Komarova, N.L. & Wang, L. (2004). Initiation of colorectal cancer: where do the two hits hit? Cell Cycle 3(13).
Komarova, N.L. (2004) Genomic Instability in Cancer: Biological and Mathematical Approaches. Cell Cycle 3(8) 1081-5.
Komarova, N.L. (2004) Does cancer solve an optimization problem? Cell cycle 3(7).
Nowak, M.A., Michor, F., Komarova, N.L. & Iwasa, Y. (2004) Dynamics of tumor suppressor gene inactivation. Proc. Natl. Acad. Sci. 101, pp. 10635-10638.
Komarova, N.L. & Wodarz, D. (2004) The optimal rate of chromosome loss for cancer initiation and progression. Proc. Natl. Acad. Sci. 101(18), pp. 7017-7021.
Komarova, N.L. & Wodarz, D. (2003) Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy. Cancer Research 63(20), pp. 6635-42.
Komarova, N.L., Sengupta, A. & Nowak, M.A. (2003) Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. Jour. of Theor. Biol. 223(4), pp. 433-450.
Michor, F., Iwasa, Y., Komarova, N.L. & Nowak, M.A. (2003) Local regulation of homeostasis favors chromosomal instability. Current Biology, 13, pp. 581-584.
Komarova, N.L., Lengauer, C., Vogelstein, B. & Nowak, M.A. (2002) Dynamics of genetic instability in sporadic and familial colorectal cancer. Cancer Biology and Therapy , 1(6), pp. 685-692.
Nowak, M.A., Komarova, N.L., Sengupta, A., Jallepalli, P.V., Shih, I.-M., Vogelstein, B. & Lengauer, C. (2002) The role of chromosomal instability in tumor initiation, Proc. Natl. Acad. Sci. 99(25), pp. 16226-16231.