We determine the average size of the Φ-Selmer group in any quadratic twist family of abelian varieties having an isogeny Φ of degree 3 over any number field. This has several applications towards the rank statistics in such families of quadratic twists. For example, it yields the first known quadratic twist families of absolutely simple abelian varieties over Q, of dimension greater than one, for which the average rank is bounded; in fact, we obtain such twist families in arbitrarily large dimension. In the case that E/F is an elliptic curve admitting a 3-isogeny, we prove that the average rank of its quadratic twists is bounded; if F is totally real, we moreover show that a positive proportion of these twists have rank 0 and a positive proportion have 3-Selmer rank 1. We also obtain consequences for Tate-Shafarevich groups of quadratic twists of a given elliptic curve. This is joint work with Manjul Bhargava, Robert Lemke Oliver, and Ari Shnidman.