Using Mathematics to Design Cancer Vaccines

Abstract:  "How much?", "How often?", "Where?" The answers to these three
questions are crucial in the design of cancer vaccines: treatments designed
to trigger an improved immune response to an existing tumor.   Mathematical
models that describe tumor growth in tissue, the immune response, and the
administration of different therapies can suggest treatment strategies that
optimize treatment efficacy and minimize negative side-effects.  However,

Complete Kahler manifolds with nonnegative curvature: examples and related results

Speaker: 

Bo Yang

Institution: 

UC San Diego

Time: 

Tuesday, April 9, 2013 - 4:00pm

Location: 

RH 306

The uniformization conjecture states that any complete noncompact Kahler manifold with positive bisectional curvature is biholomorphic to C^n.  Perhaps one of reasons that the problem is difficult is lack of examples. Recently assuming U(n) symmetry Wu and Zheng gave a systematic construction on examples of such metrics,  we will talk about some related results.

A brief account of my life in academia

Speaker: 

Jiaping Wang

Institution: 

University of Minnesota

Time: 

Tuesday, April 23, 2013 - 12:00pm to 1:00pm

Location: 

NatSci2 1201

After quickly explaining my mathematical research, I will mention my current involvement in the Institute for Mathematics and its Applications and reminisce on my graduate study experience at UCI.

Hamiltonian Monte Carlo and Its Variations

Speaker: 

Babak Shababa

Institution: 

UCI

Time: 

Monday, March 11, 2013 - 3:00pm

Location: 

RH 306

Improving the efficiency of Markov Chain Monte Carlo algorithms is an active area of re-

search in statistics. I will start this talk by providing a brief overview of Hamiltonian Monte

Carlo (HMC), which improves the computational eciency of the Metropolis algorithm by

reducing its random walk behavior. This of course requires numerical simulation of Hamilto-

nian dynamics and costly evaluation of the gradient of the log density function. Next, I will

present our recent work on improving HMC by ``splitting" the Hamiltonian in a way that

allows much of the movement around the parameter space to be done at low computational

cost. I will then discuss Riemannian Manifold HMC (RMHMC), which further improves

HMC's performance by exploiting the geometric properties of the parameter space. The ge-

ometric integrator used for RMHMC however involves implicit equations that require costly

numerical analysis (e.g., fixed-point iteration). I will finish my talk by presenting our recent

work on developing an explicit geometric integrator that replaces the momentum variable in

RMHMC by velocity.

The regularity of limit space

Speaker: 

Bing Wang

Institution: 

University of Wisconsin-Madison

Time: 

Tuesday, April 16, 2013 - 4:00pm

Location: 

RH 306

This is a joint work with Tian. We study the structure of the limit space of a sequence of almost
Einstein manifolds, which are generalizations of Einstein manifolds. Roughly speaking, such manifolds are the
initial manifolds of some normalized Ricci flows whose scalar curvatures are almost constants over space-time in the
$L^1$-sense, Ricci curvatures are bounded from below at the initial time. Under the non-collapsed condition, we show that the limit space of a
sequence of almost Einstein manifolds has most properties which is known for the limit space of Einstein
manifolds. As applications, we can apply our structure results to study the
properties of K\"ahler manifolds.

On the movement of a boundary-spike solution of a semilinear parabolic equation

Speaker: 

Izumi Takagi

Institution: 

Mathematical Institute, Tohoku University, Sendai 980-8578, Japan

Time: 

Monday, March 11, 2013 - 4:00pm to 5:00pm

Host: 

Location: 

Rowland Hall 340

 

We consider the initial-boundary value problem for a single
semilinear parabolic equation with small diffusion rate under the
homogeneous Neumann boundary condition. Bates, Lu and Zeng proved the
existence of a normally hyperbolic invariant manifold for this type of
problem. The manifold consists of functions with a spike on the
boundary, by which we mean that the function attains its maximum at
exactly one point on the boundary and decays exponentially outside a
small neighborhood of the maximum point. Moreover, they proved that the
principal part of the movement of the maximum point of the solution is
the gradient flow of the mean curvature function of the boundary. We are
interested in the movement of the spike near the critical point of the
mean curvature function. In this talk we establish the algorithm to
derive the asymptotic expansion of the equation of motion for the peak
point.

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