Changhan He


UC Irvine


Monday, February 12, 2024 - 4:00pm to 5:00pm


RH 306

Cells make decisions by communicating with other cells and receiving signals from their environment. Computational tools have been developed to infer cell–cell communication through ligands and receptors using single-cell transcriptomics. However, current methods focus only on signals sent by the measured cells, overlooking received signals from the external system. In this talk, exFINDER, a computational approach identifying external signals received by cells in single-cell transcriptomics datasets, will be introduced. Then we will delve into the analysis of associated ligand-target signaling networks. Furthermore, we will discuss the potential integration of computational methods and deterministic models for inferring cell lineages.