Jun Allard




Friday, April 15, 2022 - 4:00pm to 5:00pm



MSTB 124

Living cells exhibit many forms of spatial-temporal dynamics, including recently-discovered traveling waves. Cells use these traveling waves to organizer their insides, to improve cell-cell communication, and tune their ability to move around the body. Some of these traveling waves arise from excitability (positive feedback) and non-local coupling (dynamics that spread spatially on timescales much faster than the timescale of wave motion). In collaboration with graduate students at UC Irvine, our research has studied two traveling waves involving the mechanics of the cytoskeletal protein actin: one that is approximately equivalent to a reaction-diffusion system [Barnhart et al, 2017, Current Biology], and one that is not [Manakova et al, 2016, Biophys J]. For the non-reaction-diffusion wave, we demonstrate conditions for wave travel analogous to ones previously derived for reaction-diffusion waves. We also demonstrate the existence of a "pinned" regime of parameter space absent in the equivalent reaction-diffusion system.